Cisplatin mechanism of hearing loss

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August undefined, 2024

Web2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the … WebApr 17, 2024 · Late-onset hearing loss is known to occur long after cessation of cisplatin treatment, and these study results suggest that this delayed hearing loss may be related to long-retained cisplatin in the cochlea. Until researchers make significant progress in preventing cisplatin ototoxicity in cancer therapy, it is crucial to continue identifying ...

Oral Administration of Caffeine Exacerbates Cisplatin-Induced …

WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the … WebThe SGN apoptosis and related hearing loss induced by cisplatin were alleviated after co-treatment with the autophagy activator rapamycin, whereas these were exacerbated by the autophagy inhibitor 3-methyladenine, indicating that instead of inducing SGN death, autophagy played a neuroprotective role in SGNs treated with cisplatin both in ... how far is it from scituate ma to quincy ma

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did... WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … WebFeb 1, 2024 · loss of appetite loss of balance loss of hearing lower back or side pain nausea or vomiting painful or difficult urination pinpoint red spots on skin ringing or … high backed folding steps

Hearing Loss in Pediatric Cancer Survivors Treated With Cisplatin

WebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available. WebApr 14, 2024 · Hearing aids can protect people from the risk of developing dementia associated with hearing loss, including Alzheimer's disease, according to a new study published in the medical journal The Lancet.. Two previous landmark studies published by the Lancet Commission in 2024 and 2024 showed that hearing loss is the number-one … high backed garden chairWeb1 hour ago · Fresh bamboo shoots (Chimonobambusa quadrangularis) are subjected to senescence (e.g., lignification and browning) during postharvest storage. This study … high backed garden chairs uk

"WebApr 26, 2024 · Cisplatin primarily affects the high frequencies in both ears and is permanent. The loss of hearing can cause a severe impact on the quality of life, … " - Cisplatin mechanism of hearing loss

Cisplatin mechanism of hearing loss

Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by ...

WebFeb 9, 2016 · INTRODUCTION. Ototoxicity, manifesting as hearing loss, tinnitus, and/or vertigo, is a well-established toxicity associated with a subgroup of antineoplastic therapies that include platinum chemotherapy and radiation or surgery involving the ear and auditory nerve. Supportive care agents, such as aminoglycoside antibiotics and loop diuretics ...

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WebMar 1, 2024 · Although the mechanisms behind cisplatin-associated ototoxicity have not been completely explained, it may mainly involve ROS accumulation in the inner ear, causing a significant increase in lipid peroxidation, consumption of intracochlear antioxidants, and calcium influx, subsequently inducing apoptosis5. WebMar 26, 2024 · Acquired hearing loss may have multiple causes, but one of the common causes in childhood follows treatment for childhood cancer with cisplatin. For a sound to be perceived, it has to travel through the …

WebSep 1, 2024 · Cisplatin for injection can cause ototoxicity, which is cumulative and may be severe. Consider audiometric and vestibular function monitoring. Ototoxicity is manifested by tinnitus, hearing loss in the high frequency range (4,000 to 8,000 Hz) and/or decreased ability to hear normal conversational tones. WebApr 7, 2024 · The benefit of Pedmarqsi is preventing cisplatin-induced hearing loss, as evaluated in a phase III, randomised, open-label study in children with standard-risk hepatoblastoma and treated with cisplatin alone or in combination with Pedmarqsi. The most common side effects are vomiting, nausea, hypernatraemia, hypophosphataemia …

WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did... WebMar 15, 2024 · The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.2 …

WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating …

WebSpecifically, E1A/Ras- transformed S47 cells show increased sensitivity to cisplatin and paclitaxel, and comparable transactivation of GLS2 and SCO2, compared to cells with WT p53. high backed leather armchairsWebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs (Spankovich et al., 2016). In an alternative rodent … how far is it from scottsdale to grand canyonWebJul 3, 2024 · Mechanisms that may underlie cisplatin-induced ototoxicity include excessive ROS, inflammation, cellular uptake of cisplatin, and autophagy, which result in cell death. Preclinical results have … high backed leather wing chairWebSep 20, 2024 · The primary outcome was hearing loss according to American Speech-Language-Hearing Association (ASHA) criteria, assessed at baseline and 4-weeks after … how far is it from seahouses to beamishWebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs (Spankovich et al., 2016). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. high backed garden chairsWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to … how far is it from scranton to phillyWebJul 2, 2024 · The ABR threshold shift in animals treated with caffeine + R -PIA + cisplatin was 1.0 ± 1.0, 3.3 ± 1.7 and 4.2 ± 0.8 at 8, 16 and 32 kHz, respectively. These findings suggest that single oral ... high backed full support swing